منابع مشابه
A Rac-cGMP Signaling Pathway
The small GTPase Rac and the second messenger cGMP (guanosine 3',5'-cyclic monophosphate) are critical regulators of diverse cell functions. When activated by extracellular signals via membrane signaling receptors, Rac executes its functions through engaging downstream effectors such as p21-activated kinase (PAK), a serine/threonine protein kinase. However, the molecular mechanism by which memb...
متن کاملGrueneberg ganglion olfactory subsystem employs a cGMP signaling pathway.
The mammalian olfactory sense employs several olfactory subsystems situated at characteristic locations in the nasal cavity to detect and report on different classes of odors. These olfactory subsystems use different neuronal signal transduction pathways, receptor expression repertoires, and axonal projection targets. The Grueneberg ganglion (GG) is a newly appreciated olfactory subsystem with ...
متن کاملThe Grueneberg Ganglion olfactory subsystem employs a cGMP signaling pathway
The mammalian olfactory sense employs several olfactory subsystems situated at characteristic locations in the nasal cavity to detect and report on different classes of odors. These olfactory subsystems use different neuronal signal transduction pathways, receptor expression repertoires, and axonal projection targets. The Grueneberg Ganglion (GG) is a newly-appreciated olfactory subsystem with ...
متن کاملcGMP signaling pathway is involved in Leyding cell stress response
The ability of stress to interfere with the Leydig cell steroidogenesis has been published previously by others and our laboratory, but the intracellular signaling pathways involved in this process have not been identified and described precisely. In this study, we examined the effects of immobilization stress (1 × 120 min, 2 × 120 min within 2 days, and 10 × 120 min within 10 days) on nitric o...
متن کاملA novel pathway of cGMP
Background Cardiac atrial natriuretic peptide (ANP) regulates arterial blood pressure, moderates cardiomyocyte growth, and stimulates angiogenesis and metabolism. ANP binds to the transmembrane guanylyl cyclase (GC) receptor, GCA to exert its diverse functions. This involves a cGMPdependent signaling pathway preventing pathological [Ca]i raises in myocytes. In chronic cardiac hypertrophy, howev...
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ژورنال
عنوان ژورنال: Cell
سال: 2007
ISSN: 0092-8674
DOI: 10.1016/j.cell.2006.11.048